Nans Neuromodulation Journal Club

Overview

The lack of understanding of the underlying mechanisms of deep brain stimulation (DBS) is a major challenge in choosing personalized stimulation parameters in movement disorders. Here we investigate the modulations in local field potentials (LFP) induced by the therapeutic high-frequency (130-180Hz) and non-therapeutic low-frequency (20Hz) electrical stimulation of the subthalamic nucleus (STN) in Parkinson’s disease patients. We show that the electrical stimulation evoked a compound activity (ECA) but only therapeutic stimulation induced high-frequency oscillations (~300Hz, HFO), as it has been observed with dopaminergic treatment. Furthermore, the relative degree of enhancement in the HFO power was related to the timing/frequency of stimulation pulses relative to the phase of ECA.
We propose that high-frequency stimulation tunes the neural oscillations to their healthy/treated state, similar to pharmacological therapy, and the stimulation frequency to maximize these oscillations can be inferred from the phase of ECA waveforms of individual subjects. The induced HFOs can, therefore, be utilized as a biomarker of successful re-calibration of the dysfunctional circuit generating PD symptoms.
Target Audience: Neuroscientists, Biomedical Engineers, and Clinicians. NANS invites all faculty, students and post docs to attend!
Presenter and Co-Author
Musa Ozturk, PhD
Postdoctoral Fellow
Ince Lab, Department of Biomedical Engineering
University of Houston
Moderator
Ilknur Telkes, PhD MSc
Postdoctoral Fellow
Pilitsis Lab, Department of Neuroscience and Experimental Therapeutics
Albany Medical College