Overview

In this webinar, we will discuss the relationship between received stimulation dose and brain response (dose-response assessment) in frequently used noninvasive brain stimulation technologies; transcranial electric stimulation (tES), transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT). Here, we will be focused on methodological aspects of integrating electric fields (EFs) using computational head models (CHMs) as an indicator of stimulation dose with fMRI data as a sign of functional response in brain stimulation studies. We will present our systematic review to summarize previous tES/TMS/ECT studies that integrated head models with fMRI data to investigate dose-response relationships. Lastly, we discuss writing a consensus paper on how cortical electric fields could be integrated with fMRI data in a clinical trial to test dose-response relationships at both group and individual levels.

Agenda

10:00-10:05: Introduction of INTF Webinar
10:05-10:15: Opening Talk: Dose-response relationships in brain stimulation studies (Hamed Ekhtiari- Co-chair, University of Minnesota, USA)
10:15-10:25: Core Talk 1: Are current flow models fit for purpose? (Sven Bestmann, UCL Queen Square Institute of Neurology, UK),
10:25-10:35: Core Talk 2: Optimizing the spatial precision of seizure therapy through e-field modeling (Sarah H. Lisanby, National Institute of Mental Health, USA),
10:35-10:45: Core Talk 3: Dose-response relationships in NIBS, based on integrating head models with fMRI data: a systematic review with computational recommendations (Ghazaleh Soleimani, University of Minnesota, USA),
10:45-10:55: Core Talk 4: Optimization of tES based on integrating computational head and brain models with structural and functional neuroimaging data (Giulio Ruffini, Neuroelectrics Barcelona, Spain),
10:55-11:30: Discussants: Different methods for integrating head models with fMRI in brain stimulation studies (3-4 slides per discussant)
● Using electric-field modeling to define rTMS stimulation intensity during a working memory task. (Lysianne Beynel, National Institute of Mental Health, USA)
● Dose-response in network‐targeted multichannel transcranial direct current stimulation and network based connectivity (Lucia Mencarelli, IRCCS Santa Lucia Foundation, Rome, Italy),
● A Future of Current Flow Modeling for tES (Carys Evans, UCL Queen Square Institute of Neurology, UK),
● Electric field modeling and optimization approaches for individualized targeting (Zhi-De Deng, National Institute of Mental Health, USA),
● Predicting functional connectivity changes in response to in-scanner tES using person-specific models (Aprinda Indahlastari, University of Florida, USA),
● The importance of individual electric field on the neurophysiological outcomes of tDCS and TMS (Mohsen Mosayebi-Samani, Leibniz Research Center, Dortmund, Germany),
● Is electric field simulation related to neuromodulation? (Daria Antonenko, Universitätsmedizin Greifswald, Germany),
11:30-11:50: Q&A and Group Discussion
11:50-12:30: Conclusion and the Road Ahead