Overview

In this webinar, we will discuss in-vivo/in-vitro studies including animal/cellular experimentation and animal models in the recent history of non-invasive brain stimulation (NIBS), and we will question its ramification. We will be focused on how animal/cellular research can inform dose-response relationships in NIBS. We will then raise the issue of the relations and interactions between experiments on animals and experiments on humans.

Agenda

10:00-10:05: Introduction of INTF Webinar
10:05-10:10: Opening Talk 1: Dose-Response Dilemma in Non-Invasive Brain Stimulation (Sarah H Lisanby, Co-chair, National Institute of Mental Health, USA)
10:10-10:15: Opening Talk 2: Importance of animal studies in NIBS for human (Alexander Opitz, Co-chair, University of Minnesota, USA)
10:15-10:25: Core Talk 1: Notes on the limits of electric field sensitivity (Marom Bikson, City College of New York, USA)
10:25-10:35: Core Talk 2: State/dose dependency of electrical stimulation from in-vivo and in-vitro electrophysiological perspective (Flavio Frohlich, University of North Carolina, USA)
10:35-10:45: Core Talk 3: Importance of dosimetry in animal tES and TMS studies (Angel Peterchev, Duke University, USA)
10:45-10:55: Core Talk 4: Cortical excitability in non-human primate model of TMS (Colleen Hanlon, Wake Forest University, USA)
10:55-11:30: Discussants: How to inform dose-response relationships in NIBS studies with animal/cellular research? (2-3 slides per discussant)
● Insights from animal, cellular, and modeling studies to inform dose-response (Ivan Alekseichuk, University of Minnesota, USA)
● Brain stimulation in psychiatry: Is there a need for electric field standardization? (Andreas Vlachos, University of Freiburg, Germany)
● Spatially and temporally targeted neuromodulation by tES in rats (Mihály Vöröslakos, New York University, USA)
● Using animal models to improve the design and application of tES in humans (Javier Márquez-Ruiz, Pablo de Olavide, Spain)
● MR-ARFI as a Dose-response measure in transcranial ultrasound stimulation (TUS): In vivo evidence (Kim Butts Pauly, Stanford)
● Transcranial brain perfusion imaging for dose response of transcranial ultrasound neuromodulation: animal model evidence (Elisa Konofagou, Columbia University, USA)
11:30-11:50 Q&A and Group Discussion
11:50-12:30 Conclusion and the Road Ahead