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Upcoming Neuromodulation Event

Brain Stimulation at the Microscopic Scale: Multiscale Models and Cellular Studies at The 6th International Brain Stimulation Conference

Workshop

Sunday, February 23, 2025 at 9 AM - 4:30 PM (Local Time) | Kobe, Japan

Room#: Room 301 - International Conference Room


Overview

Scientific Scope

The workshop will cover the most recent experimental and modeling results on the cellular mechanisms of brain stimulation mechanisms. The workshop focuses on the latest concept and recording/analysis tools characterizing cell and network response to brain stimulation, and new computational modeling techniques. Concepts are relevant to all forms of non-invasive (e.g., TES, tDCS, tACS, TMS) and in invasive (e.g., direct electrical stimulation, DBS, invasive magnetic stimulation) electrical stimulation. Translational aspects including dose optimization based on individual imaging and recording, pulse shape optimization, plasticity induction, and novel cellular targets such as vascular stimulation. The workshop will also address advanced brain ultra-structure and imaging techniques as they provided new data for understanding brain stimulation mechanisms and modeling.

Workshop Logistics

Lunch and coffee breaks will be provided, with priority for those who RSVP. The workshop is free to all Brain Stimulation Conference registrants, but space is limited so RSVP is strongly encouraged to ensure your spot. The workshop is open to participants of all backgrounds though geared to those interested in cellular techniques, modeling, and signal processing. This is the only non-industry sponsored workshop the day before the Brain Stimulation main program. Participants are welcome to review the complete program and may decide to attend only a portion of the workshop and/or move between this workshop and parallel industries sponsored workshops. Attendees are welcome to arrive before the program (~8 AM) or stay after the program (4:30 PM) for pre/post conference networking. However, no refreshments will be provided at these times.

Organizers

-Aman Aberra (Dartmouth) - aman.s.aberra@dartmouth.edu
-Sergey Makaroff (WPI, Mass General Hospital) - snmakaroff@wpi.edu
-Marom Bikson (CCNY) - bikson@ccny.cuny.edu
-Technical manager: Gregory M Noetscher - gregn@wpi.edu

Joint workshop of the Regional Brain and Human Body Modeling Conference (BHBM, R13MH137971), the International Brain Stimulation Conference, and NYC Neuromodulation Conference

Program

In Person Presentations

9:00AM - 9:25AM Alexander Opitz (U Minnesota, USA) - Biophysical modeling and measurements of activating local cortical circuits
9:25AM - 9:50AM Cynthia Steinhardt, Larry Abbott (Columbia U, USA) - Pulsatile and galvanic population-level stimulation using integrate-and-fire models
9:50AM - 10:15AM Daniel Berger, Jeff Lichtman (Harvard U, USA) - Structure of the human brain at high resolution
20 mins break
10:35AM - 11:00AM Aman Aberra (Dartmouth, USA) - Illuminating subcellular mechanisms of electrical stimulation using optical physiology and computational modeling
11:00AM - 11:25AM Esra Neufeld (IT'IS Foundation, ETH, Switzerland) - Temporal interference at the microscopic scale
11:25AM - 11:50AM Andreas Vlachos (U Freiburg, Germany) - Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity
11:50AM - 12:15PM Shelley Fried (Massachusetts General Hospital, USA) - Recording responses of single cells to magnetic stimulation delivered from sub-millimeter hand-wound coils
12:15PM - 1:10PM Lunch Break
1:10PM - 1:35PM Matthew Johnson (U Minnesota, USA) - Reconstruction and Biophysical Modeling of Patient-Specific Neural Fiber Pathways for Improving DBS Targeting
1:35PM - 2:00PM Luis J Gomez (Purdue, USA) - Bidomain biophysical modeling of brain stimulation
2:00PM - 2:25PM Padma Sundaram (Massachusetts General Hospital, USA) - Experimental TES and TMS stimulation of Purkinje cells of turtle cerebellum
2:25PM - 2:50PM Angelique Paulk (Mass General, USA) - Electrophysiological, programming, and neural activity analysis skills to understand how direct electrical stimulation could alter the neural dynamics
20 mins break
3:10PM - 3:35PM Sergey Makaroff (Worcester Poly, Massachusetts General Hospital, USA) - Fluctuations of applied electric field at the cellular level in SEM samples lower brain stimulation thresholds
3:35PM - 4:00PM Konstantin Weise, Thomas Knoesche (Max Planck Leipzig, Germany) - Statistical method to account for electric field distortions around neurons of SEM brain maps when simulating thresholds
4:00PM - 4:25PM Gregory Noetscher and Marom Bikson (WPI, CCNY, USA) - Microvascular modulation of brain stimulation with realistic large microvascular networks
4:30PM - 5:30PM Workshop Social: Questions to presenters and discussion

Pre-recorded asynchronous presentations prepared exclusively for the workshop – made available online and broadcast on demand

-Bethanny Danskin (Allen Inst. for Brain Science, USA) - IARPA Phase I and Phase III mouse brain samples with detailed microstructure and synaptic connectivity maps

-Boshuo Wang (Duke Univ, USA) - Physics of E-field Modeling of Brain Stimulation

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