Overview

Non-invasive neuromodulation tools capable of selectively manipulating neural systems in the human brain are needed to advance our neuroscientific understanding of brain function and develop novel therapeutic strategies. In this workshop, students and researchers can learn about state-of-the art computational, experimental, and clinical methods in transcranial magnetic/electric/ultrasound stimulation (TMS, tACS, tFUS). The workshop includes lectures and hands-on sessions on: Advanced computational modeling Closed-loop brain stimulation Combinations with neuroimaging (EEG, MRI) and connectomics Cutting-edge clinical applications Mechanistic and animal studies

Program

(All time in CDT/Minnesota), all events will be streamed online unless marked §

June 8 (Day 1)

09:00-09:30 ― On-site registration

09:15-09:30 ― Welcome note

09:30-12:00 ― Session I: Connectomics targeting in clinics and research (Chair: Christine Conelea, University of Minnesota)

09:30-10:00 ― Paul Croarkin (Mayo Clinic), Recent adaptations and innovations of TMS interventions for adolescents

10:00-10:30 ― Hamed Ekhtiari (University of Minnesota), Concurrent tES/fMRI: towards non-invasive individualized causal mapping of human brain functions

10:30-11:00 ― Coffee break and group discussions§

11:00-11:30 ― Lysianne Beynel (National Institute of Mental Health), fMRI targeting approach to enhance rTMS efficacy

11:30-12:00 ― Lucia Isabel Navarro (Massachusetts General Hospital), Concurrent TMS/fMRI – towards non-invasive high-resolution causal mapping of human brain functions

13:15-15:45 ― Session II: Selected topics in neuromodulation

13:15-13:45 ― Hubert Lim (University of Minnesota), Can ultrasound directly activate neurons or peripheral nerves?

13:45-14:15 ― Axel Thielscher (Technical University of Denmark), Dose calculations for tFUS: status and challenges

14:15-14:45 ― Coffee break and group discussions§

14:45-15:15 ― Ivan Alekseichuk (University of Minnesota), TACS effects on neural populations and cognition

15:15-15:45 ― Aaron Boes (University of Iowa), Investigating the effects of TMS on the human brain with intracranial EEG

16:00-18:00 ― Welcome meet-up§

June 9 (Day 2)

09:30-12:00 ― Session III: Real-time brain stimulation

09:30-10:00 ― Christoph Zrenner (Centre for Addiction and Mental Health, Canada), Closed-loop real-time EEG-TMS: three current challenges

10:00-10:30 ― Sara Hussain (University of Texas at Austin), Uncovering oscillatory mechanisms of human motor control with phase-dependent TMS

10:30-11:00 ― Coffee break and group discussions§

11:00-11:30 ― Miles Wischnewski (University of Minnesota), Phase-specific real-time targeting of mu and beta oscillations in the motor cortex

11:30-12:00 ― Alik Widge (University of Minnesota), Controlling brain networks through oscillatory synchrony

13:15-15:45 ― Session IV: Advances in computational modeling (Chair: Alexander Opitz, University of Minnesota)

13:15-13:45 ― Oula Puonti (Danish Research Center for Magnetic Resonance), Validation of electric field simulations: closing the gap between simulation and stimulation

13:45-14:15 ― Sumientra Rampersad (University of Massachusetts Boston), Quantifying uncertainty in simulations of non-invasive brain stimulation

14:15-14:45 ― Coffee break and group discussions§

14:45-15:15 ― Ting Xu (Child Mind Institute), Automated MRI segmentation of the nonhuman primates for prospective head modeling: challenges and method

15:15-15:45 ― Angel Peterchev (Duke University), Multiscale modeling of cortical neuron activation by transcranial magnetic stimulation

16:00-17:00 ― Blitz talks

June 10 (Workshops)§

9:30-10:30 ― SimNIBS 4 preview and walkthrough§ (Oula Puonti, Axel Thielscher)

11:00-12:00 ― "Bring your own modeling problem" and laptop§

10:30-12:00 ― Introduction to brain stimulation for undergraduate students§ (Alexander Opitz, Zachary Haigh, Taylor Berger)

13:15-14:30 ― Demo of closed-loop TMS set-up§ (Miles Wischnewski, Ivan Alekseichuk) @ Opitz lab

13:15-14:45 ― Demo of robot-assisted TMS set-up§ (Mo Chen, Alana Lieske) @ Masonic Institute for the Developing Brain