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Overview

Recordings of all talks will be posted on the Conference website at Massachusetts General Hospital with distribution through the network of Harvard Medical School
All review presentations: from 20 to 30 min (including ~3-5 min for questions) All research presentations: from 10 to 20 min (including ~2-5 min for questions)

Note all times given below are Eastern Standard Time (EST), USA

All presentations from students (including post doctorate and part-time students) are eligible for student competition 2023 (the student must be the first, presenting author). A monetary award ($1,000, 2x$500, and 2x$300) and an award plaque will be mailed to the winners within a month after the end of the conference.

Conference-based publications are accepted for a Special Edition of Physics in Medicine and Biology here.

Conference Organizers:

Kyoko Fujimoto, Gregory M. Noetscher, Konstantin Weise, Thomas R. Knösche, Sofia R. Fernandes, Zhi-De Deng, Hanbing Lu, Aapo R. Nummenmaa, Sergey N. Makaroff

Conference Zoom link

Program

Day 1: Thursday August 17, 2023 (Online presentations)

Opening session - Chair: Kyoko Fijumoto

8:05 – 8:15 AM:Opening Remarks – Bruce Rosen

8:15 – 8:30 AM:Computational Neuroscience: NeuroTech and Digital Health at WPI – Jean King

8:30 – 8:45 AM: BRAIN Initiative Sensors Program and other recent NIMH initiatives – Yvonne Bennett

8:45 – 9 AM: Q&A, Coffee break

Session 1: New Modeling Methods and Pipelines (In person and online presentations) – Chair: Gregory Noetscher (US ARMY DEVCOM-SC and WPI)

9 – 9:30 AM: A pipeline for personalized modeling of electrical neuromodulation: From image segmentation to brain activity - Fariba Karimi, Taylor H. Newton, Bryn Lloyd , Javier Garcia Ordonez, Melanie Steiner , AmirAli Farokhniaee, Jan Paul Triebkorn, Huifang Wang, Viktor Jirsa, Niels Kuster, and Esra Neufeld

9:30 – 10 AM: A flexible optimization framework for transcranial electric stimulation, temporal interference stimulation and tumor treating fields - Konstantin Weise, Kristoffer H. Madsen, Thomas R. Knösche , Anders Korshøj , Axel Thielscher

10 – 10:15 AM:Coffee Break

10:15 – 10:35 AM: CutFEM forward modeling for MEG source analysis - Tim Erdbrugger, Andreas Westhoff, Malte Holtershinken, Jan-Ole Radecke, Yvonne Buschermohle, Alena Buyx, Fabrice Wallois, Sampsa Pursiainen , Joachim Gross , Rebekka Lencer, Christian Engwer and Carsten Wolters

10:35 – 10:55 AM: Boundary element fast multipole method for mesoscale and multiscale brain modeling - William Wartman, Manas Rachh, Vishwanath Iyer, Leslie Greengard, Gregory Noetscher, Mohammad Daneshzand, Matti Hämäläinen, Jyrki P. Ahveninen, Konstantin Weise, Tommi Raji, Aapo Nummenmaa , Sergey Makaroff

10:55 – 11:50 AM: Questions to presenters, lunch (US)/dinner (Europe)

Session II: New Modeling Methods and Targets Including Cellular Modeling – TMS – Chairs: Thomas Knösche (Max Planck Inst) Aapo Nummenmaa (Massachusetts General Hospital)

11:50 AM – 12:10 PM:Thomas Knösche, Ole Numssen, Gesa Hartwigsen, Konstantin Weise - Smart TMS Mapping – Novel Approaches to Mapping and Modeling

12:10 – 12:30 PM:Nahian Ibn Hasan, Dezhi Wang, Luis J. Gomez - Application of Fast E-Field Solvers in Developing Individualized Optimal Transcranial Magnetic Stimulation

12:30 – 12:50 PM:Mohammad Daneshzand - Assessment of modular multichannel TMS array combined with EMG and EEG

12:50 – 1:10 PM:Luis Gomez1 , Hao Zhang, Johann Guilleminot - Uncertainty quantification of TMS simulations considering MRI segmentation errors

1:10 – 1:30 PM: Aaron Miller, Thomas R. Knösche, Konstantin Weise - A neural mass model of TMS induced Iwaves in the primary motor cortex

1:30 – 1:40 PM: Questions to presenters, coffee break

Session III: New Modeling Methods and Targets – Spinal cord stimulation and novel stimulation targets – Chairs: Chair: Sofia Rita Fernandes (U Lisbon), Zhi-De Deng (NIH/NIMH)

1:40 – 2 PM:Comparison of phrenic nerve stimulation setups using an anatomically detailed volume conductor model of the neck - Laureen Wegert, Alexander Hunold, Marek Ziolkowski , Tim Kalla, Irene Lange, Jens Haueisen

2 – 2:20 PM:Modelling challenges in non-invasive spinal stimulation: perspectives on current state-of-the-art - Sophia Rita Fernandes

2:20 – 2:40 PM:Magnetic stimulation allows focal activation of the mouse cochlea - Jae-Ik Lee, Shelley Fried

2:40 – 2:50 PM: Questions to presenters, coffee break

Session IV: Practical aspects of TMS modeling – Chairs: : Ravi Hadimani (Virginia Commonwealth University), Lucia Navarro de Lara (Martinos Center)

2:50 – 3:10 PM:Interaction between TMS and MRI - Lucia Isabel Navarro de Lara

3:10 – 3:25 PM:Innovative transcranial magnetic stimulation coil designs for small animals utilizing multimagnetic materials for enhanced E-field focality - Mohannad Tashli, Aryan Mhaskar, George Weistroffer, Deepak Kumbhare, Mark S. Baron, Ravi L. Hadimani

3:25 – 3:40 PM:Anatomically and conductively accurate rat head phantoms for transcranial magnetic stimulation - Wesley Lohr

3:40– 3:55 PM:A biological model of spinal and peripheral motor pathways for TMS-induced MEPs - Shih-Cheng Chien1,2, Christian Röse, Peng Wang, Helmut Schmidt, Thomas R. Knösche, Konstantin Weise

3:55– 4:10 PM:Stimulation of Cortical Spinal Tract during Cerebellar TMS - Maria Nazarova

4:10– 4:25 PM: Prediction of intermittent theta burst stimulation response using machine learning - Mehmet A. Ozdemira, Onan Guren, Mouhsin M. Shafi, Recep A. Ozdemir

4:10– 4:25 PM: TMS coil design with fast multipole method - Leah Morales

4:40– 5:10 PM: What exactly are we modeling? – A virtual tour of TMS Core Lab, Athinoula A. Martinos Ctr. for Biomedical Imaging - Aapo Nummenmaa

5:10– 5:20 PM: Questions to presenters, coffee break

5:30 PM:Conference dinner: Meet at the ferry terminal

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Day 2: Friday, August 18th

Session V: MEG Practice and MEG Modeling (In person and online presentations) - Chairs:Padma Sundaram (MGH), Hermann Kutschka (MPI)

7 – 7:20 AM: Virtual tour of MEG OPM facility at Max Planck - Burkhard Maess, Hermann Kutschka

7:20 – 7:35 AM: Setup of a room temperature MEG system at the Martinos Center - Padma Sundaram, Mainak Jas

7:35 – 7:45 AM: Forward calculations for OPM MEG - Mainak Jas

7:45 – 7:55 AM: Forward calculations for cerebellar MEG in epilepsy - Teppei Matsubara, Padma Sundaram

7:55 – 8 AM: Questions to presenters, coffee break. Please consider asking more detailed questions offline.

Session VI: Cellular Level Based Modeling – Chairs: Hanbing Lu (NIDA), Luis Gomez (Purdue University)

8 – 8:17 AM: Directional sensitivity of cortical neurons towards TMS induced electric fields - Konstantin Weise, Torge Worbs, Benjamin Kalloch, Victor H. Souza, Aurélien Tristan Jaquier, Werner Van Geit, Axel Thielscher, Thomas R. Knösche

8:17 – 8:34 AM: What neuronal elements are stimulated by TMS? Simulations and experiments on awake rats - Hanbing Lu, Hieu Nguyen, Charlotte Li, Samantha Hoffman, Yihong Yang

8:34 – 8:51 AM: Cellular mechanisms of TMS in cerebellum - P. Sundaram

8:51 – 9:08 AM: Computational E-field dosimetry with intissue neuron analysis using a boundary element approach - David M. Czerwonky, Luis J. Gomez

9:08 – 9:25 AM: Cortical neuron tissue analysis with boundary element fast multipole method – the extracellular problem - Alton Miles, Gregory M. Noetscher, Zhen Qi, Konstantin Weise, Aapo Nummenmaa , Sergey Makaroff

9:25 – 9:30 AM: Questions to presenters, coffee break. Please consider asking more detailed questions offline.

Session VII: (Micro) Vascular Stimulation and Modeling – Chair: Jonathan Poliment (MGH) (Online presentations)

9:30 – 10 AM: Neuro-vascular modulation: what a new mechanism suggests about how brain stimulation works and how to interpret hemodynamic imaging? – Marom Bikson

10 – 10:20 AM: Modeling basis of fMRI: Modeling susceptibility-caused variations of B0 in microvascular networks - Grant Hartung, Jonathan Polimeni, Aapo Nummenmaa, Sergey Makaroff

10:20 – 10:30 AM: Coffee Break

Session VIII: tDCS Modeling (In person and online presentations) – Chair: Benjamin C. Newphew (WPI)

10:30 – 10:50 AM: Targeted tDCS in sensorimotor networks: A functional connectivity study - Vasco Marques da Silva, Alexandre Andrade, Sofia Rita Fernandes, Hugo Alexandre Ferreira

10:50 – 11:10 AM: Dose and intersubject variability analysis for anodal tDCS stimulation over motor cortical network - Pablo Franco-Rosado, M. Amparo Callejón, Javier Reina-Tosina, Laura M. Roa, Juan F Martin-Rodriguez, Pablor Mir

11:10 – 11:15 AM: Questions to presenters, coffee break. Please consider asking more detailed questions offline.

Session IX: Development and Assessment of Modeling Methods (In person and online presentations) - Chairs: Manas Rachh (Ctr. for Comp. Mathematics, Flatiron Institute, NYC), Zhi-De Deng (NIH/NIMH)

11:15 – 11:33 AM: An Adaptive HRefinement Method for the Boundary Element Fast Multipole Method for Quasi-static Electromagnetic Modeling - William A Wartman, Konstantin Weise, Manas Rach, Leah Morales, Zhi-De Deng, Aapo Nummenmaa7 , Sergey N Makaroff

11:33 – 11:51 AM: New Huygens surface-based modeling approach to peripheral nerve stimulation - Mathias Davids

11:51 – 12:09 PM: Comparing the performance of beamformer algorithms in estimating orientations of neural sources - Yvonne Buschermöhle, Malte Höltershinken, Tim Erdbrügger, Jan-Ole Radecke, Andreas Sprenger, Till R. Schneider, Rebekka Lencer, Joachim Gross, Carsten H. Wolters1

12:09 – 12:27 PM: A full head model to analyze intra and extra-cochlear electric currents under different cochlear implant stimulation strategies - M.Amparo CallejónLeblic, A. Fratter, F. Ropero-Romero, J. ReinaTosina , S. SánchezGómez

12:27 – 1 PM: Questions to presenters, lunch (US)/dinner (Europe) Software talk over the lunch: Haowen Wei, Columbia Univ.
PhysioLabXR: A software platform in Python for multi-modal brain-computer interface and realtime experiment pipelines (Zoom, 12:40 PM – 1 PM)

Session X: WPI Research: Analyzing Functional and Structural MRI Data for Rehabilitation and Diagnosis (In person and online presentations) – Chairs: Padma Sundaram (Massachusetts General Hospital), Aapo Nummenmaa (Massachusetts General Hospital)

1 – 1:20 PM: Studying brain activation during exoskeleton-facilitated hand movement using fMRI at the intersection of assistance and rehabilitation - Tess B. Meier, Christopher J. Nycz, Gregory S. Fischer

1:20 – 1:40 PM: A mindfulness intervention for hypertension alters resting state functional connectivity networks - Justin J. Polcari, Ryan J. Cali, Benjamin C. Nephew, Frances Saadeh, Eric Loucks, Jean A. King

1:40 – 2 PM: Enhancing timely detection of Alzheimer’s dementia and mild cognitive impairment using a deep learning model and structural MRIs - Sarah Semy, Senbao Lu, Benjamin Nephew

2 – 2:10 PM: Questions to presenters, coffee break

Session XI: Modeling Transcranial Focused Ultrasound (In person and online presentations) – Chairs: Mohammad Daneshzand (Massachusetts General Hospital)

2:10 – 2:30 PM: A general deep learning ultrasound solver for real-time tFUS navigation in individualized skull models - Thiago P. Maffei Dardis, Bastien Guérin

2:30 – 2:50 PM: Localized Drug Plasma Protein Unbinding through Transcranial Focused Ultrasound - Evgenii Kim

2:50 – 3 PM: Questions to presenters, coffee break

Session XII: High-Frequency Modeling (In person and online presentations) – Chairs: James Brown, Micro Systems Engineering, Inc., Gregory Noetscher (US ARMY DEVCOM-SC and WPI)

3 – 3:20 PM: Evaluating the probability of MRI RF-induced unintended stimulation for an implantable loop recorder - James E. Brown, Paul J. Stadnik, Jeffrey A. Von Arx, Dirk Muessig,

3:20 – 3:40 PM: Full-body detailed Toyota human model for radio-frequency simulations in Ansys Electronics Desktop - Peter J. Serano

3:40 – 4 PM: A new FDA MDDT tool for implant heating modeling - Gregory M. Noetscher, Peter Serano

4 – 4:10 PM: Questions to presenters, coffee break

4:10 – 4:20 PM: Announcement of Student Competition Winners

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