59

Sessions

250+

Speakers

3600+

Attendees

11000+

Session Registrations

Scheduled sessions



Completed Virtual Poster session

Submit by: Tuesday, December 15th 11:59 PM (ET)
Starts: Friday, December 18th
Ends: Tuesday, December 22nd

Session Description:

The NYC Neuromodulation poster session will be held online from Dec 18th, 2020 9 AM (ET) until Dec 22, 2020 5 PM (ET). All poster details will be posted here by Dec 18th, 2020 9 AM (ET). From Dec 18th, 2020 9 AM (ET) until Dec 22, 2020 5 PM (ET) all posters will be available with an open intuitive comment session and (optional) Zoom poster presentations. Abstract submission is open until December 15th, 2020 at 11:59 PM (ET).

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Completed Updates on Transcranial Direct Current Stimulation (tDCS) : Applications and Mechanisms

Starts: Monday, April 20th 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 3 hours

Session Chair:

Marom Bikson, (The City College of New York)

Session Speakers:

Marom Bikson: Opening Remarks
(9:02) Michael Nitsche: Updates on tDCS dosing: Polarity, Intensity, and Interval.
(9:27) Lucas Parra: Updates and perspective on tDCS mechanisms: tDCS is Hebb.
(9:52) Bernadette Gillick: Controversies, Vulnerabilities and Possibilities: New Frontiers for Neuromodulation in Early Injury to the Pediatric Brain
(10:17) Adam Woods Updates and perspective on tDCS in age-related cognitive decline.
(10:42) Shirley Fecteau Updates and perspective on tDCS in addiction.
(11:07) Andre Brunoni: tDCS in depressive disorders.
(11:32) Vince Clark: Updates and perspective on tDCS effects on Cognition

Session Description:

This session provides a broad overview of the state-of-the-art in transcranial Direct Current Stimulation considering techniques, mechanisms, and applications. It is intended for an audience that is already familiar with tDCS. The format will be 20 minute talks by each speaker, followed 10 minute Q&A. Registation limit is 80.

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Completed #NEUROMODULATION & #SOCIALMEDIA: THE CASE OF FAILED #SPINALCORDSTIMULATION THERAPY FROM THE PERSPECTIVE OF #FACEBOOK #SUPPORTGROUPS

Session Chair:

GEORGIOS MATIS MD, MSc, PhD - Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany

Session Description:

The spinal cord stimulation (SCS) therapy is a cost-effective option for patients with chronic pain. However, various complications such as technical and biologic / postsurgical ones have been associated with this treatment. The scope of this session is to explore the complaints of dissatisfied SCS-patients who are active on Facebook (FB). The main topics of interest will be: information gathering before a SCS-implantation or explantation, post-implantation or post-explantation problems, legal issues, and questions about reps. The session should be of interest to all neuromodulators who wish to maximize their patients´ satisfaction and to those who are actively involved in spreading awareness about neuromodulation with the aid of FB or other social media platforms.


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Completed Neurophysiological effects of spinal cord stimulation for chronic pain management

Starts: Monday, April 20th 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 2 hours

Session Chair:

Scott Lempka (University of Michigan)

Session Presenters:

Ilknur Telkes (Albany Medical Center) – Electroencephalography during spinal cord stimulation for pain
Michael Staudt (Albany Medical Center) – Neuromonitoring for spinal cord stimulation lead placement under general anesthesia
Stefano Palmisani (Guy’s and St. Thomas’ Hospital) – Electrophysiological response to spinal cord stimulation
Martine Bordeleau (Virginia Commonwealth University) – Quantitative sensory testing in patients with spinal cord stimulation

Session Description:

This session will focus on clinical studies examining the neurophysiological response to spinal cord stimulation (SCS) for chronic pain management. Session topics will include insights gained from electroencephalography during SCS, neuromonitoring during SCS lead placement, sensory testing, and evoked compound action potentials recorded from the spinal cord during SCS.



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Completed ROAST: TES modeling made easy

Starts: Monday, April 20th 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 1 hour

Session Chair:

Yu (Andy) Huang, PhD, Memorial Sloan Kettering Cancer Center, CCNY-MSK AI Partnership

Session Description:

A brief tutorial on how to use ROAST for quick and easy electric field modeling and optimization for transcranial electrical stimulation (TES). Please contact andypotatohy@gmail.com for specific topics you want to hear during this session


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Additional content:
Demo script >>
Unanswered questions >>


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Completed Noninvasive VNS for Adult and Neonates (Brain Injury and Opioid Withdrawal)

Starts: Monday, April 20th 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 2 hours

Session Chair:

Bashar W. Badran Ph.D., Medical University of South Carolina

Session Speakers:

Dorothea Jenkins M.D. Medical University of South Caorlina
Navid Khodaparast, PhD (Spark Biomedical)

Session Description:

Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) has emerged as a promising way to activate vagal-mediated neuroplasticity. This symposium will highlight the work of Dr. Badran and Dr. Jenkins using taVNS to accelerate motor rehabilitation post-brain injury. Dr. Badran will discuss the technical details of the Motor Activated Auricular Vagus Nerve Stimulation (MAAVNS) system he has pioneered and Dr. Jenkins will follow with how she implements MAAVNS to help neonates learn how to feed on a bottle on their own.



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Completed Cutting-Edge DRG Stimulation Approaches and Applications

Starts: Monday, April 20th 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 2 hours

Session Chair:

Lee E. Fisher, Phd (University of Pittsburgh)

Session Speakers:

Ameya Nanivadekar, MS (University of Pittsburgh)
Robert Graham, MS (University of Michigan)
Andrew Shoffstall, PhD (Case Western Reserve University)
Chaitanya Gopinath, PhD (University of Pittsburgh)
Douglas Weber, PhD (University of Pittsburgh)

Session Description:

Stimulation of the dorsal root ganglia (DRG) has recently gained traction as an effective therapy for treating pain. Multiple research labs are actively pursuing projects to improve efficacy and understand underlying mechanisms of DRG stimulation, and are applying DRG stimulation to novel applications, such as controlling bladder function, restoring motor control after neurological injury, and restoring sensory function after amputation.



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Completed SimNIBS: Comprehensive and easy modeling and optimization of TES and TMS electric fields

Starts: Monday, April 20th 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 1 hour

Session Speakers:

Oula Puonti, Guilherme Saturnino, Axel Thielscher
Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre & Department of Health Technology, Technical University of Denmark

Session Description:

In this walkthrough, we will demonstrate both basic and advanced features of SimNIBS (www.simnibs.org), and highlight a few key aspects to get accurate simulation results.



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Completed Addressing Opioid Benzodiazapine and Stimulant Addiction using Advanced Neurostimulation Techniques

Starts: Monday, April 20th 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 1 hour

Session Speakers:

Nicholas J Dogris, Ph.D.

Session Description:

This session reports the outcomes of tDCS and tACS neurostimulation on patients who engaged in a 45 day drug detoxification program. Pre and Post EEG analysis shows significant differences as compared to controls. Patients reported improved sleep with significant decreases in symptoms of depression and anxiety. Dr. Dogris is the director of neuroscience services at FHE in Deerfield Beach, Florida. He can be reached at ndogris@fhehealth.com.



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Completed How to Go to Space - TMS in Zero Gravity

Starts: Monday, April 20th 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 2 hours

Session Chair:

Bashar W. Badran Ph.D., Medical University of South Carolina

Session Speakers:

Donna Roberts M.D., Medical University of South Carolina

Session Description:

We are just beginning to understand how spaceflight may impact brain function. Dr. Badran and Roberts have recently conducted a TMS experiment onboard a parabolic flight. Dr. Roberts will discuss her work investigating brain changes of astronauts onboard the International Space Station. Dr. Badran will discuss the technical details and considerations of creating a space-ready TMS Lab - including building custom TMS helmets will discuss the findings of their study. We will then have an open Q&A panel for the audience.



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Completed EXPLORATION OF HIGH AND LOW FREQUENCY OPTIONS FOR SUB-PERCEPTION PAIN RELIEF USING NEURAL DOSING PARAMETER RELATIONSHIPS: THE HALO STUDY

Starts: Monday, April 20th 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 30 mins

Session Chair:

Dr Simon Thomson MBBS - Consultant in pain medicine and neuromodulation

Session Description:

The programming of sub-perception spinal cord stimulation has been poorly understood with commercially supported beliefs that one parameter or one waveform is supreme. The PROCO RCT showed that the same clinical pain relief could be achieved at 10kHz, 7 kHz , 4kHz and 1kHz providing, as we first coined, that the "neural dose" was optimised. By increasing the pulse width as the frequencies reduced the same pain relief was achieved. PROCO RCT also showed that this had to be targeted with both inter and intra patient variation in optimal point of stimulation. Finally PROCO RCT showed that the charge delivery is NOT constant, it reduced by a third from 10kHz to 1kHz.
The HALO study explores sub-perception SCS below 1000Hz to as low as 10Hz. We followed the neural dosing algorithm but used a novel field shape that could give a balanced charge delivery over a larger surface area, presuming to take in multiple optimal sites of stimulation. The results will be presented and set into the wider context that serves to explain how the commercial stimulation and waveform parameters are points along the neural dose curve.

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Completed Cognitive and Emotional Interventions Paired with tDCS

Starts: Monday, April 20th 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 2 hours

Session Chair:

Tehila Eilam-Stock, PhD, NYU Langone Department of Neurology

Session Speakers:

Dr. Vince Clark, The Mind Research Network, USA
Dr. Stevan Nikolin, UNSW School of Psychiatry, Black Dog Institute, Australia
Dr. Jessica Richardson, University of New Mexico, USA
Dr. Sarah Myruski, Hunter College CCNY, USA
Dr. Leigh Charvet, NYU Langone, USA
Dr. Elizabeth Galletta, NYU Langone, USA

Session Description:

tDCS can improve therapeutic outcomes when paired with behaviorally-based clinical interventions. This session will review the role of tDCS to enhance the learning that occurs in the context of various therapies. We will highlight some of the current approaches to improve memory and other cognitive functions, speech/language rehabilitation, and for the management of psychiatric conditions such as anxiety and depression. We will address which tools are optimal to combine with tDCS, including those that may be used in the home setting.



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Completed Causal role of neural oscillations in the organization of brain networks

Starts: Monday, April 20th 2020 | 4 PM (EDT) / 21:00 (GMT+1)
Duration: 2 hours

Session Chair:

Flavio Frohlich PhD, Director of the Carolina Center for Neurostimulation at the University of North Carolina at Chapel Hill

Session Speakers:

Justin Riddle, PhD "Causal role of delta-beta coupling in decision-making: implications for anhedonia"
Wei Angel Huang, PhD Candidate "Causal role of the higher-order thalamocortical oscillations in sustained attention”
Christopher Walker, PhD "Causal role of blood glucose in regulating cortical network oscillations & cortico-spinal excitability”
Trevor McPherson, BS "Causal role of theta and alpha oscillations in output-gating"

Session Description:

In this session, the Carolina Center for Neurostimulation at the University of North Carolina at Chapel Hill presents their recent work on the causal role of neural oscillations in the organization of brain networks. Each talk is 10 minutes with 5 minutes of Q&A.



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Completed Invasive and Non-invasive Neuro-Stimulation for Evaluation and Recovery of Motor Function

Starts: Monday, April 20th 2020 | 5 PM (EDT) / 22:00 (GMT+1)
Duration: 2 hours

Session Chair:

Ela B. Plow PhD PT Cleveland Clinic Foundation, Cleveland, OH

Session Speakers:

Trisha Kesar PhD PT Emory University, Atlanta, GA
David Cunningham PhD MetroHealth Rehabilitation Institute, Cleveland, OH
Yin-Liang Lin PhD PT National Yang Ming University, Taiwan
Jason B Carmel MD PhD, Columbia University, NY
Michael Borich PhD DPT Emory University, Atlanta, GA.
Adriana Conforto MD Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Ken Baker PhD Cleveland Clinic Foundation, Cleveland, OH
Robert Chen MA, MBBChir, MSc, FRCPC, Toronto Western Hospital Toronto, Ontario

Session Description:

This session provides updates on invasive (deep) and non-invasive (transcranial, peripheral) neuro-stimulation techniques employed to study and promote motor functional recovery in neurologic disease. Emphasis will be placed on novel paradigms, underlying mechanisms and characterization of responders and non-responders to improve clinical utility of neuromodulation. The format will be 10 minute talks given by each speaker, followed 5 minute Q&A.
Ela Plow: Opening Remarks
Trisha Kesar: Pairing Spinal & Supra-spinal Mechanisms To Enhance LE Recovery potential Following Stroke
Jason B Carmel: Paired brain and spinal cord stimulation to promote recovery of movement
Adriana Conforto: Effects of Peripheral Somatosensory Neurostimulation. Get talk slides here >>
David Cunningham: Investigating Mechanisms of Neuromodulation in Responders vs. Non-responders. Get talk slides here >>
Yin-Liang Lin: Understanding Inter-hemispheric Inhibition in Stroke to develop Severity-Specific Brain Stimulation. Get talk slides here >>
Michael Borich: Inter-hemispheric Neuromodulation for UE recovery In Stroke. Get talk slides here >>
Ken Baker: Cerebellar DBS to promote Upper Extremity Motor Function following Stroke
Robert Chen: Pairing TMS and DBS in Parkinson’s Disease and Dystonia. Get talk slides here >>
Ela Plow: Closing Remarks



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Completed NYC Neuromodulation Fast-Presentation Competition for Emerging Scientists - Part 1

Starts: Monday, April 20th 2020 | 7 PM (EDT) / Tuesday, April 21 00:00 (GMT+1)
Duration: 1 hour

Session Moderator:

Marom Bikson (City College of New York of CUNY)

Reviewers:

Benjamin Hampstead (University of Michigan)
Jessica Richardson (University of New Mexico)
Danny JJ Wang (University of Southern California (USC))

Presenters:

Shreya Parchure - BDNF Gene Polymorphism Predicts Response to cTBS in Stroke Patients
Sheida Rabipour - Enhancing Memory in Subjective Cognitive Decline with Electricity & Expectations
Jorja Shires - Pain but no Gain: Young Adults Show No WM Training Benefit with or Without tDCS
Peiyuan (Boki) Wang - Modifying Motor Skill Learning via Neuromodulation of Frontoparietal Networks
Linfeng Han- Effects of Transcranial Direct Current Stimulation of Frontotemporal Semantic Processing Regions on Value-Incentivized Memory Encoding
Lari M. Koponen - Double containment coil with optimized winding mounting for quiet transcranial magnetic stimulation

Session Description:

Open to "emerging" who are pre-PhD or within 3 years of completing the PhD. 7 minutes presentations ONLY with 3 minutes Q+A. A panelist of judges will select winners who will be recognized. These sessions are timed to be at the end of each conference day.
All presenter slots are filled for this session. If you would like to present, check out Part 2 here



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Completed COVID-19 and brain stimulation labs/studies/researchers across the world: Sharing experiences, difficulties and best practices

Starts: Tuesday, April 21st 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 2 hours

Session Chairs:

Marom Bikson (The City College of New York)
Hamed Ekhtiari (Laureate Institute for Brain Research, USA)

Session Speakers:

China: Ti-Fei Yuan (Shanghai Mental Health Center)
Germany: Andrea Antal (University of Göttingen)
Iran: Mohammad Reza Ay (National Brain Mapping Lab)
Italy: Graziella Madeo (Fondazione Novella Fronda)
Italy: Paola Marangolo (University of Naples Federico II)
Brazil: Ester Miyuki Nakamura-Palacios (Federal University of Espírito Santo)
Austria: Claus Lamm (University of Vienna)
New Zealand: Dirk De Ridder (University of Otago)
Japan: Akimasa Hirata (Nagoya Institute of Technology)
Portugal: Jorge Almeida (University of Coimbra)
UK: Charlotte Stagg (University of Oxford)
USA: Leigh Charvet (NYU Langone Health)

Session Description:

In the solidarity with people/scientists in across the world in such a complex situation, in a joint collaboration between INTF, ISAM-NIG and INTAM, we planned a one-hour session on "challenges with brain stimulation labs/studies/researchers during COVID-19 across the world: sharing experiences, difficulties and best practices" in this online meeting. Each speaker will give a three-minute brief-talk sharing experiences/challenges. We will also ask the audience to share their own experiences.



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Completed Progress in Concurrent Neuroimaging + Neurostimulation: Challenges and Opportunities for Neuroergonomic Applications

Starts: Tuesday, April 21st 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 3 hours

Session Chairs:

Hasan Ayaz (Drexel University, USA)
Frederic Dehais (ISAE-SUPAERO, France)

Session Speakers:

Shanbao Tong (Shanghai Jiao Tong University, China)
Stephane Perrey (University of Montpellier, France)
Davide Valeriani (Harvard University, USA)
Ryan McKendrick (Northrop Grumman, USA)
Junfeng Sun (Shanghai Jiao Tong University, China)
Stefanie Enriquez Geppert (University of Groningen, Netherlands)
Adrian Curtin (Drexel University, USA)
Jesse Mark (Drexel University, USA)

Session Description:

This session will report on the recent progress for the integrated use of diverse neuroimaging and neurostimulation approaches with a focus on everyday life and neuroergonomic applications. Technologies ranging from functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) on neuroimaging side, paired with transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and focused ultrasound stimulation (FUS) on the neurostimulation side will be discussed.
Davide Valeriani on Neurotechnologies for Human Cognitive Augmentation
Shanbao Tong on Optogenetic Applications
Stephane Perrey on Transcranial Electrical Stimulation and Functional Near Infrared Spectroscopy
Junfeng Sun on Focused Ultrasound Stimulation and Imaging
Stefanie Enriquez Geppert on Neurofeedback For Enhanced Executive Functioning
Ryan McKendrick on Transcranial Direct Current Stimulation & Functional Near Infrared Spectroscopy
Adrian Curtin on Transcranial Magnetic Stimulation & Functional Near Infrared Spectroscopy
Jesse Mark on Transcranial Electrical Stimulation & Functional Magnetic Resonance Imaging



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Completed Mechanisms of Pain and Spinal Cord Stimulation

Starts: Tuesday, April 21st 2020 | 10 AM (EDT) / 15:00 (GMT+1)
Duration: 2 hours

Co-chairs/Moderators:

Steve Prescott, SickKids Hospital/University of Toronto
Rosana Esteller, Boston Scientific

Presenters:

10:00-10:15 Steve Prescott (SickKids Hospital/University of Toronto): Inhibitory neural circuits in the dorsal horn and their roles in pain modulation.
10:15-10:30 Rosana Esteller (Boston Scientific Neuromodulation): Using Evoked Potentials to Study SCS Mechanisms: Bipole and Novel Field
10:30-10:45 Warren Grill or Lab Representative (Duke University): Cellular Effects of Kilohertz Frequency SCS
10:45-11:00 Ru-Rong Ji (Duke University): Non-neuronal mechanisms of chronic pain.
11:00-11:15 Beth Winkelstein (University of Pennsylvannia) Supraspinal Responses to Spinal Cord Stimulation: Regional & Mode Variations in Painful Radiculopathy
11:15-11:30 Tianhe Zhang (Boston Scientific Neuromodulation): Computational Modeling of Concurrent SCS Affecting Multiple Neuronal Targets

Session Description:

Although epidural spinal cord stimulation (SCS) has emerged as an effective neuromodulation therapy for chronic neuropathic pain, only through understanding of the mechanisms underlying SCS can the therapy be improved further. This series of talks will provide an overview of potential neuronal and non-neuronal targets and mechanisms for SCS and how these mechanisms shape the design of therapy from academic and industrial perspectives



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Completed Neuromodulation of cognition in older adults: from behavior to brain imaging and machine learning

Starts: Tuesday, April 21st 2020 | 10 AM (EDT) / 15:00 (GMT+1)
Duration: 1 hour

Moderator:

Adam J. Woods, University of Florida

Speakers:

Adam J. Woods, University of Florida
Stacey Alvarez-Alvarado, University of Florida
Alejandro Albizu, University of Florida

Session Description:

This symposium will discuss recent findings from the NIH funded Stimulated Brain Study investigating the impact of two weeks of tDCS paired with cognitive training in older adult. Dr. Woods will present findings on the impact of tDCS on working memory performance and functional connectivity. Dr. Alvarez-Alvarado will present findings on the impact of tDCS paired with cognitive training on magnetic resonance spectroscopy measures of GABA and glutamate/glutamine (Glx). Mr. Albizu will present results from combining individualized MRI-derived finite element modeling of tDCS current with machine learning to understand the relationship between current intensity, direction of current flow and behavioral response to tDCS.



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Completed Navigated Transcranial Magnetic Stimulation in the clinic and the lab: an overview of current practice and future directions

Starts: Tuesday, April 21st 2020 | 10 AM (EDT) / 15:00 (GMT+1)
Duration: 2 hours

Session Chair:

Bas Neggers (UMC Utrecht, Brain Science Tools)

Speakers:

Nickolay Smirnov (Neurosoft)
Rick Dijkhuizen (UMC Utrecht)
Jord Vink (UMC Utrecht, Brain Science Tools)

Session Description:

Transcranial magnetic stimulation (TMS) is an area of non-invasive neuromodulation that has made the transition from the laboratory into the clinic successfully, and is experiencing a rapid pace of innovation. New and ever more effective protocols follow each other quickly, and best practices have been established and approved for clinical use by regulatory authorities in many regions, such as the FDA in the US and CE marking by notified bodies in the EU. This process is very much ongoing.
In this session, we will introduce the mechanisms and equipment behind TMS, provide an overview of the many treatment and diagnostic protocols that now exist, and will highlight their clinical and research potential. We will elucidate new developments such as the advantages of MRI guidance of TMS treatment, new navigated TMS options for diagnostic measures in neurology, and new techniques that deepen our understanding and optimization of TMS practices. The session will end with a live workshop of several new TMS, neuronavigation and cortical mapping techniques, where the audience can interact with the operators through a live video session.
Programme:
Nickolay Smirnov (Neurosoft): What happens in the brain when we deliver TMS pulse? (including an introduction into TMS protocols)
Bas Neggers (UMCU, Brain Science Tools): Current practice and future directions of MRI guided TMS and navigated cortical mapping
Rick Dijkhuizen + Jord Vink: state of the art of MRI guided rTMS treatment and longitudinal navigated motor mapping of subacute stroke: the BSTARS trial
Jord Vink: Live workshop of therapeutic rTMS, diagnostic monophasic TMS, navigated MEP cortical mapping.
Each lecture/workshop above will take 30 minutes
Note: this session is hosted by neuromodulation researchers from UMC Utrecht (The Netherlands), and supported by the medical device companies Soterix Medical (New York), Brain Science Tools (the Netherlands) and Neurosoft (Russia).



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completed State-of-the-art of numerical head modeling in tES: methods and applications

Starts: Tuesday, April 21st 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 2 hours

Session Chair:

Ricardo Salvador

Session Speakers:

Giulio Ruffini, Neuroelectrics
Maria Chiara Biagi, Neuroelectrics
Roser Sanchez-Todo, Neuroelectrics
Carla Sendra Balcells, Neuroelectrics

Session Description:

umerical head models in transcranial electrical stimulation (tES) have become a powerful and robust tool for planning stimulation. Due to the development of computational algorithms to segment MRIs, it is now possible to create on a personalized way realistic volume conductor head models. These head models can be used to analyze commonly used montages, in a retrospective manner and to determine the characteristics of the electric field distribution in the head. They can also be combined with montage optimization algorithms that allow for the determination of the dose parameters (electrode positions and currents) that optimally stimulate specific target areas in the subject’s brain. Moreover, the next generation of models should combine passive physical properties with more sophisticated representations of the physiological effects of tES, providing a link with measures obtained from fMRI/EEG, enabling the creation of a more sophisticated personalization of the optimization protocols.
In this symposium we will discuss new developments that allow for a faster creation of personalized head models and how to leverage these head models to plan experiments in tES. We will also present a new physiological modeling approach for tES and electrophysiological biomarkers of neuromodulation in ADHD.
List of presentations: CNN MRI segmentation for fast and robust optimization of the human brain, C Balcells
A Biologically Realistic Laminar Neural Mass Modelling Framework for tES, R Sanchez-Todo
Targeting consciousness brain networks with tCS in minimally conscious state patients, MC Biagi
Improving sham protocols in tCS with montage optimization: actisham, R Salvador
EEG biomarkers of tDCS neuromodulation of executive functions in healthy and ADHD populations, L Vall

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Completed Targeting of Transcranial Electric Stimulation

Starts: Tuesday, April 21st 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 3 hours

Session Chair:

Host: Lucas C. Parra, The City College of New York
Co-Host: Yu (Andy) Huang, Memorial Sloan Kettering Cancer Center, CCNY-MSK AI Partnership

Session Speakers:

11:00 EDT Nir Grossman Non invasive deep brain stimulation via temporally interfering electric fields
11:20 EDT Mihály Vöröslakos Spatially and temporally targeted neuromodulation by transcranial Intersectional Short Pulse (ISP) stimulation
11:40 EDT Pulkit Grover The mechanics of Temporal Interference stimulation, and how to improve the stimulation focus
12:00 EDT Mariano Fernandez Unification of optimal targeting methods in Transcranial Electrical Stimulation
12:20 EDT Carsten Wolters New forward and inverse methods for targeted TES
12:40 EDT Guilherme B Saturnino A Comprehensive, Efficient, and Accessible Framework for TES Optimization
13:00 EDT Sumientra Rampersad Modeling and optimization of transcranial temporal interference stimulation
13:20 EDT Yu (Andy) Huang Comparison of HD-TES with interferential and intersectional-pulsed stimulation

Session Description:

A number of techniques have been proposed to target specific brain areas by selecting optimal electrode locations, using arrays of electrodes or using novel waveform. This includes high-definition stimulation, interference stimulation, inter-sectional pulsed stimulation. This session intends to bring together experts in this field to share new result and explain existing approaches.



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Completed Modulators of tDCS effects

Starts: Tuesday, April 21st 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 2 hours

Session Chair:

Michael Nitsche

Session Description:

Lorena DeMelo: Impact of serotonin on tDCS effects
Elham Ghanavati: Impact of Dopamine on tDCS effects
Ali Salehinejad: Chronotype-dependent effects of tDCS
Mohsen Mosayebi: Stimulation protocol-dependent effects of cathodal tDCS
Desmond Agboada: Stimulation protocol-dependent effects of anodal tDCS

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Completed Lunchtime Virtual Poster Sessions - 5 slides, 10 minutes each (Open to All)

Starts: Tuesday, April 21st 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 2 hours

Session Chair:

Bashar W. Badran Ph.D., Medical University of South Carolina

Session Speakers:

Confirmed Presenters:
Kevin Caulfield Medical University of South Carolina
Melanie Wiley Medical University of South Carolina
James Lopez Medical University of South Carolina
Holly Fleischmann Medical University of South Carolina
Adrianna Giuffre, University of Calgary
Sudeshna Chatterjee, University of Florida
Xu Zhang, University of Connecticut
Sean Christensen, Medical University of South Carolina
Stephen Bornheim, Université de Liège

Session Description:

This forum, hosted by MUSC graduate students will offer an opportunity for trainees to present their data in a virtual poster format. Each trainee will have up to 10 minutes to go over data and present to the group and field questions and comments from attendees. It is a rather informal discussion - bring your lunch and support your fellow junior scientists.
The talks in this session will be judged by the conference awards committee as part of the "NYC Neuromodulation Competition for Emerging Scientists.



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Completed Digital Tools, Sensing, and Patient-Centric Neuromodulation

Starts: Tuesday, April 21st 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 3 hours

Session Chair:

Erika Ross, Ph.D. - Director, Applied Research - Abbott Neuromodulation
JoJo Platt - President - Platt & Associates, Inc.

Session Speakers:

Guillermo Cecchi, Ph.D. - Principal Research Lab Member, IBM T.J. Watson Research Center
Sam Hamner - Cala Health
Brian Pepin, Ph.D. - CEO, Founder - Rune Labs
Dan Rizzuto, Ph.D. - CEO - Nia Therapeutics
Sridevi Sarma, Ph.D. - Associate Professor, Biomedical Engineering, Johns Hopkins
Theodoros Zanos, Ph.D. - Assitant Professor, Feinstein Institute
Yagna Pathak, Ph.D. - Senior Research Scientist, Abbott Neuromodulation

Session Description:

Presentations will include:
- Voice acoustics and content as digital signal in mental health - Cecchi
- Wearable neuromod therapies for at-home care and remote monitoring - Hamner
- Decision support and adaptive programming -> removing burden from clinicians and patients - Peppin
- The Nia Advanced Neurostimulation System: A next-gen deep-brain stimulation platform with integrated sensing and cloud connectivity - Rizzuto
- Towards Closed-Loop Peripheral Nerve Stimulation for Chronic Pain - Sarma
- The future of neuromodulation with digital health integration - Pathak
- Neural Data Analytics - Zanos
There will be a comprehensive panel discussion and Q&A following the presentations.



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Completed How stakeholder engagement is driving neuromodulation development to address a priority within the end-user community

Starts: Tuesday, April 21st 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 1 hour

Session Chair/Moderator:

Bill Fertig, United Spinal Association

Session Speakers:

Tracey Wheeler, The Craig H. Neilsen Foundation
Dennis Bourbeau, Cleveland FES Center & Louis Stokes VA Medical Center
Jennifer French - Neurotech Network

Session Description:

This session is sponsored by the North American Spinal Cord Injury Consortium to highlight how multiple stakeholders are working together to develop solutions to a pressing issue among the end-user population. Neuromodulation strategies to address the bladder and bowel dysfunctions related to spinal cord injury are an emerging field. Still bladder and bowel issues remain the top priorities for people living with the condition. How can neuromodulation address this? This session will highlight the collective efforts of the funders, researchers, clinicians and the spinal cord injury communities to bring forth solutions. Topics of discussion include the a multi-stakeholder workshop gathering input for a funding mechanism, the roadmap for neuromodulation development today and the future as well as how the end-user population is playing a major role in it.



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Completed Bioelectronic Medicine at Feinstein: labs, projects, opportunities and a journal

Starts: Tuesday, April 21st 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 1 hour

Session Chair:

Stavros Zanos (Assistant professor, Head of Translational Neurophysiology lab)

Session Speakers:

Theodoros Zanos (Assistant professor, Head of Neural & Data Science lab)
Timir Datta (Assistant professor, Head of Bioelectronics lab)
Valentin Pavlov (Professor, Executive editor Bioelectronic Medicine journal)

Session Description:

A session of three 10-15 min talks presenting some of the labs, projects and people in the recently founded Institute of Bioelectronic Medicine at Feinstein Institutes for Medical Research. Opportunities at the Institute for students, post-docs and collaborators will be discussed. Also, a brief presentation of the journal Bioelectronic Medicine will be provided by the journal's executive editor, Valentin Pavlov.



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Completed EEG modulation in naturalistic settings

Starts: Tuesday, April 21st 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 1 hour

Session Chair:

Ivan Gligorijevic, mBrainTrain LLC

Session Speakers:

Abhishek Datta, Soterix Medical
(waiting for confirmation of other participants)

Session Description:

Mobile EEG gained immense popularity in recent years because it enabled the brain recordings in freely moving environments. This mobility meant the naturalistic paradigms could be investigated in unprecedented way. While the investigated scope is wide, modulating the brain activity is of special interest. Modulation can be physiological - due to interaction with other individuals or engagement in biofeedback procedures (like visual-assisted stroke rehabilitation) or non-physiological, like tDC or tES. We will discuss the various issues, do's and don'ts in this session and try to reflect on past experience and future research directions and challenges.



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Completed Remote tDCS: Telerehabilitation in the Time of COVID-19

Starts: Tuesday, April 21st 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 3 hours

Session Chair:

Leigh Charvet PhD, NYU Langone Department of Neurology

Session Speakers:

Angelo Alonzo (Black Dog Institute, Australia)
Michael Bull (Black Dog Institute, Australia)
X. Michelle Androulakis (University of South Carolina)
Tehila Eilam-Stock (NYU Langone, Department of Neurology)
Martin Malik (NYU Langone, Department of Neurology)
Pam Best (NYU Langone, Department of Neurology)
Allan George (NYU Langone, Department of Neurology)
Matt Lustberg (NYU Langone, Department of Neurology)
Helena Knotkova (MJHS)
Kai Sherman (NYU Langone, Department of Neurology)

Session Description:

The current pandemic has served to significantly advance the use of telemedicine. This session will address the use of tDCS at home for both research and clinical applications.
Section 1 (starting 2:00 pm) will review the clinical use of remote tDCS and examples of clinical practices noting regulatory issues and billing models, with panel discussion.
Section 2 (starting 3:00 pm) will review guidelines for safe and reliable remotely supervised tDCS, presenting protocols from clinical trials, with panel discussion.
We will then open for additional discussion, with clinicians and investigators welcome to share their protocols and experiences.



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Completed High Definition tDCS: Advanced Applications, Technological Considerations, Clinical Testing Outcomes.

Starts: Tuesday, April 21st 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 2 hours

Session Chair:

Abhishek Datta, PhD, Soterix Medical

Session Speakers:

Abhishek Datta , PhD- Soterix Medical
Egas Caparelli-Daquer, MD, PhD- Rio de Janeiro State University
Head of the Lab. of Electrical Stimulation of the Nervous System (LabEEL) - Neurosurgery Unit - HUPE-UERJ
Yu (Andy) Huang, PhD, Memorial Sloan Kettering Cancer Center, CCNY-MSK AI Partnership

Session Description:

This session provides an overview of recent advances in High Definition tDCS application namely with respect to fMRI-guided targeting, closed loop application, and multi-target optimization. Additionally findings are presented from trial focused on targeting deeper structures. This session is intended for an audience already familiar with High Definition tDCS. The format will be 20 minute talks by each speaker followed by 10 minute Q&A.
Abhishek Datta: Advanced Applications and related technological considerations in High-Definition tDCS
Egas Caparelli-Daquer: Targeting deeper structures by leveraging anatomical details: Early results in Huntington Disease
Yu (Andy) Huang: Multi-Target Optimization



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Completed Cracking the Code of Sub-Perception Spinal Cord Stimulation: Recent Scientific and Clinical Learnings on Spinal Cord Stimulation

Starts: Tuesday, April 21st 2020 | 2 PM (EDT) / 19:00 (GMT+1)
Duration: 1 hour

Session Chair/Moderator:

Michael Moffitt, PhD (Boston Scientific)

Session Speakers:

1. Mike Moffitt, PhD (Boston Scientific)
2. Ismael Huertas, PhD (Boston Scientific)
3. Roshini Jain, MS (Boston Scientific)

Session Description:

1. 2:00 pm – 2:20 pm: Ongoing SCS Optimization Journey and Implications for MOA: What Works, and How it Works
2. 2:20 pm – 2:40 pm: Exploration of Sub-Perception Pain Relief Using Neural Dosing Parameters
3. 2:40 pm - 3:00 pm: Clinical Results of Combining Sub-Perception SCS and Conventional SCS Therapy



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Completed Underlying Physiology, Clinical Applications, and Commercialization of a Novel Technique for Transcutaneous Respiratory-Gated Auricular Vagus Afferent Nerve Stimulation (RAVANS)

Starts: Tuesday, April 21st 2020 | 3 PM (EDT) / 20:00 (GMT+1)
Duration: 2 hours

Session Chair:

Ronald G. Garcia, (Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA)

Session Speakers:

Vitaly Napadow, (Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA)
Roberta Sclocco, (Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA)
Samuel Hamner, (Cala Health, San Francisco, CA, USA)

Session Description:

This session will provide an overview of cutting-edge, experimental work examining the neurophysiological effects of a novel approach for respiratory-gated transcutaneous auricular vagus afferent nerve stimulation (RAVANS) and its potential therapeutic applications. Dr. Napadow will describe the basic neurophysiology of transcutaneous vagus nerve stimulation and role of respiratory gating, as well as neuroimaging applications for better understanding of RAVANS effects on pain processing. Dr. Sclocco will present fMRI assessments for RAVANS parameter optimization and novel gastric functional imaging approaches to evaluate RAVANS modulation of gastric motility in functional dyspepsia and gastroparesis. Dr. Garcia will present brain imaging and physiological data demonstrating the enhanced impact of RAVANS in the modulation of the central autonomic network, cardiovagal activity and negative mood in patients with major depression. Dr. Hamner will discuss patient-centric strategies for evaluating and commercializing wearable neuromodulation therapies to treat chronic diseases, such as RAVANS, and the role of industry-academia partnerships in supporting technology transfer.



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Completed Understanding spinal neuromodulation for SCI: Where are we today and where is it going?

Starts: Tuesday, April 21st 2020 | 4 PM (EDT) / 21:00 (GMT+1)
Duration: 1 hour

Session Chair/Moderator:

Jennifer French

Session Speakers:

Chet Mortiz, PhD, University of Washington Peter Grahn, PhD, Mayo Clinic Vivian Mushahwar, PhD, University of Alberta, Edmonton John Chernesky, Praxis Institute.

Session Description:

This session is sponsored by the North American Spinal Cord Injury Consortium. Epidural or spinal stimulation has been a hot topic for the treatment of paralysis due to spinal cord injury; however, the results from the science are not always in agreement. Where are we today in the science for both non-invasive and implanted technologies? What does the science tell us? Where is it going in the future taking into account the needs and desires of people living with SCI. This session will highlight each of these area and talk about the latest developments for recovery and early results of the SCI preference survey.

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Completed tDCS clinical effects and safety for major depressive disorder: Meta-analytic evidence

Starts: Tuesday, April 21st 2020 | 7 PM (EDT) / 00:00 (GMT+1)
Duration: 2 hours

Session Chair:

Donel Martin, University of New South Wales

Session Speakers:

Stevan Nikolin, University of New South Wales
Lais Razza, University of Sao Paulo
Adriano Moffa, University of New South Wales

Session Description:

Over the last 15 years, transcranial direct current stimulation (tDCS) has emerged as a novel treatment for Major Depressive Disorder, with demonstrated antidepressant effects. Results from clinical trials though have been mixed, which has raised important questions including: How effective is it really? Which patients are most likely to respond? What is the evidence for adverse effects? Is tDCS safe with multiple treatments? This session will address each of these questions based on the latest meta-analytic evidence. 1. Lais Razza, Sao Paulo University. tDCS clinical effects in Major Depressive Disorder.
2. Adriano Moffa, University of New South Wales. tDCS adverse effects in Major Depressive Disorder.
3. Donel Martin, University of New South Wales. tDCS cognitive effects in Major Depressive Disorder.
4. Stevan Nikolin, University of New South Wales. tDCS adverse effects with repeated treatments.



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Completed Combining neuroimaging and stimulation to study inhibition in motor plasticity

Starts: Wednesday, April 22nd 2020 | 7 AM (EDT) / 12:00 (GMT+1)
Duration: 1 hour

Session Chairs:

Charlotte Stagg, University of Oxford, UK

Session Speakers:

Joana Grigoras, University of Oxford, UK
Catharina Zich, University College London, UK
Tulika Nandi, University of Oxford, UK

Session Description:

There is increasing evidence that modulation of inhibition plays a central role in human motor plasticity. Here we discuss recent work from our lab in Oxford which uses a variety of approaches to study the role of inhibition in motor plasticity in humans. Dr Stagg will start by giving a brief overview of the evidence for inhibition in human motor plasticity. Dr Grigoras will present data from pharmacological studies using NIBS and MRI to study the causal effects of modulating GABAergic signalling during learning of a novel motor skill. Dr Zich will discuss the results from a TMS - MEG study investigating the physiological basis of neural oscillations implicated in plasticity. Finally, Dr Nandi will discuss novel NIBS approaches currently being developed which we hope will substantially expand our understanding of the neural processes underlying plasticity.



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Completed NYC Neuromodulation Fast-Presentation Competition for Emerging Scientists - Part 2

Starts: Wednesday, April 22nd 2020 | 8 AM (EDT) / 13:00 (GMT+1)
Duration: 1 hour

Session Moderator:

Marom Bikson (City College of New York of CUNY)

Reviewers:

Ela Plow (Cleveland Clinic Foundation, Cleveland, OH)
Jessica Richardson (University of New Mexico)
Danny JJ Wang (University of Southern California (USC))
Vince Clark (The Mind Research Network, USA)

Presenters:

1. Stephen Bornheim (University of Liege) “Long-term functional outcomes of repeated tDCS in acute stroke patients”
2.Ali Salehinejad (Leibniz Research Centre for Working Environment and Human Factors) “ The impact of chronotype and time of day on human cortical excitability, neuroplasticity, and cognition."
3. Daniel Gomes da Silva Machado (Universidade Federal do Rio Grande do Norte) "Effect of High-Definition and conventional transcranial direct current stimulation on exercise performance and psychophysiological responses in athletes."
5. Eric Trautmann (Columbia University) "Large-Scale Neural Recording in Nonhuman Primates using Neuropixels Probes”
5. Ellen Sutter (University of Minnesota) "Neuromodulation in Perinatal Stroke: Opportunities for Early Detection and Early Intervention"
6.Amy Vogel-Eyny (City University of New York) "What’s that Called? Effects of HD-tDCS on Lexical Accessibility of Common and Proper Nouns in Healthy Older Adults”

Session Description:

Open to "emerging" who are pre-PhD or within 3 years of completing the PhD. 7 minutes presentations ONLY with 3 minutes Q+A. A panelist of judges will select winners who will be recognized. These sessions are timed to be at the end of each conference day.



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Completed TES Electric field modeling challenges and emerging methods

Starts: Wednesday, April 22nd 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 2 hours

Session Chairs:

Zeinab Esmaeilpour (City College of New York)

Session Speakers:

Lukas Hirsch (City College of New York)-Using machine learning for robust brain segmentation for tES modeling
Essam A.Rashed (Nagoya Institute of Technology)-End-to-end semantic segmentation of personalized deep brain structures for non-invasive brain stimulation.
Dennis Truong (City College of New York) -What’s between the brain and skull? Emulating meninges in models of tDCS.
Jose Gomez-Tames (Nagoya Institute of Technology, Japan)- Significant group-level hotspots found in deep brain regions during transcranial direct current stimulation (tDCS): A computational analysis of electric fields.
Zeinab Esmaeilpour (City College of New York) -Temporal interference stimulation targets deep brain regions by modulating neural oscillations.

Session Description:

Transcranial electrical stimulation is an important, widely used stimulation modality. Yet has major technical challenges including modeling fast and accurate individualized electric field distribution, does-response relationship and targeting deep brain structures. In this symposium, we discuss novel methods to segment cortical and deep regions using emerging concepts in modeling namely machine learning to ensure segmentation. We also discuss about possibility of targeting deep structures with conventional stimulation electrodes as well as new methods of interferential stimulation.

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Completed Connecting to the Networks of the Human Brain by EEG guided closed-loop TMS

Starts: Wednesday, April 22nd 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 1 hour

Session Chairs:

Risto Ilmoniemi, Aalto University, Finland

Session Speakers:

Risto Ilmoniemi, Aalto University, Finland
Gian Luca Romani, University of Chieti-Pescara, Italy
Ulf Ziemann, University Clinic Tuebingen, Germany
Timo Roine, Aalto University, Finland
Laura Marzetti, University of Chieti-Pescara, Italy
Christoph Zrenner, University Clinic Tuebingen, Germany
Dr. Jaakko Nieminen (Aalto University, Finland)

Session Description:

This session will describe the concept, approaches and current results of the ERC Synergy project (2019-2025) ConnectToBrain. ConnectToBrain aims at making a breakthrough in multilocus TMS (mTMS) and in its use in closed-loop brain stimulation for therapeutic interventions. This will be achieved by fast and precise control over the location, direction, intensity, and timing of TMS pulses and by real-time analysis of brain activity and connectivity from EEG to guide TMS stimulation. ConnectToBrain will thus allow for gently activating neuronal circuits and couple to their natural dynamics while observing the TMS induced modulation of evoked responses and rhythms. The first 10 minutes of this session will be devoted to introducing the project overarching and specific goals as envisioned by the three PIs: Risto Ilmoniemi, Gian Luca Romani and Ulf Ziemann. In the remaining 50 minutes, the current status of the project development and of the results will be depicted by three experienced researchers in the project team. Specifically, Timo Roine will speak about the “Development of the multi-locus TMS system”, Laura Marzetti will cover the “Real-time estimation of EEG functional connectivity and brain states” and Christoph Zrenner will address the translational impact by discussing “Brain-state-dependent EEG-rTMS for plasticity induction: studies in healthy subjects, major depression and stroke”.



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Completed A discussion with the National Institutes of Health (NIH)

Starts: Wednesday, April 22nd 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 1 hour

Moderator:

Marom Bikson (The City College of New York, CUNY)

Panelists:

Dr. Sahana Kukke (NINDS.NIH)
Dr. Michael B. Wolfson (NIBIB, NIH)
Dr. Brooks Gross (NINDS, NIH)
Dr. David McMullen (NIHM, NIH)
Dr. Ralph Nitkin (NICHDm NIH)

Session Description:

Please come to this session with any questions for our NIH panelists. Michael B. Wolfson, Ph.D. is Program Director at NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB). Sahana N. Kukke, PhD is Program Director, Neural Engineering at National Institute of Neurological Disorders and Stroke (NINDS). Brooks A Gross, PhD, is a Scientific Project Manager in the Division of Translational Research at NINDS. Dr. Gross’s portfolio includes the NIH BRAIN Initiative and HEAL Initiative, and NINDS Translational Neural Devices cooperative agreements in neuropsychiatric disorders, neurotraumatic injuries, cognition, neurorehabilitation technologies, and brain-computer interfaces. David McMullen, MD, is a Program Officer at NIMH with a portfolio focused on invasive and non-invasive brain stimulation and recording devices as well as a lead on the NIH BRAIN Initiative teams focused on brain stimulation development. Ralph Nitkin, PhD, is Deputy Director, National Center for Medical Rehabilitation Research and Director, Biological Sciences and Career Development Program (Eunice Kennedy Shriver) National Institute of Child Health and Human Development (NICHD).



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Completed Mechanisms of TMS

Starts: Wednesday, April 22nd 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 2 hours

Session Chair:

Joshua Brown, M.D., Ph.D., Medical University of South Carolina

Session speakers:

Andreas Vlachos, Ph.D., University of Freiburg: "10Hz repetitive magnetic stimulation induces LTD-LTP metaplasticity"
Joshua Brown, M.D., Ph.D., Medical University of South Carolina: "TMS-induced Plasticity of the Human Motor Cortex"
Aaron Boes, M.D., Ph.D., University of Iowa: "10 Hz rTMS transiently reduces brain connectivity as measured with intracranial EEG"
Shan Saddiqi, M.D., Harvard University: "Targeted modulation of brain networks"

Session Description:

Transcranial Magnetic Stimulation is a powerful therapeutic tool, the potential of which is still being discovered. A mechanistic understanding of how TMS changes the brain can unlock this potential. This session will cover mechanistic advances across the span of molecular to behavioral plasticity including hippocampal tissue slices, human motor plasticity, intracranial electrocorticography, and functional neuroimaging.



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Completed Overviews of neuromodulation technologies for neurological and psychiatric disorders

Starts: Wednesday, April 22nd 2020 | 9 AM (EDT) / 14:00 (GMT+1)
Duration: 2 hours

Session Chair:

Milos R Popovic, University of Toronto

Session speakers:

Luka Milosevic, University of Tuebingen
William D Hutchison, University of Toronto
Taufik A Valiante, University of Toronto
Matija Milosevic, Osaka University

Session Description:

A multidisciplinary group of engineers, neuroscientists, and neurosurgeons will present the discovery process and latest findings regarding a diverse range of novel invasive and non-invasive therapeutic interventions for neurological and psychiatric disorders. Topics will include neuromodulation for movement disorders (Luka Milosevic), cognition (Bill Hutchison), epilepsy (Taufik Valiante), major depressive disorder (Milos Popovic), and brain injury (Matija Milosevic).



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Completed Emerging applications of spinal cord stimulation

Starts: Wednesday, April 22nd 2020 | 10 AM (EDT) / 15:00 (GMT+1)
Duration: 2 hours

Session Chair:

Scott Lempka (University of Michigan)

Session Speakers:

Svjetlana Miocinovic (Emory University) – Spinal cord stimulation for gait dysfunction in Parkinson's disease
Peter Grahn (Mayo Clinic) – Spinal cord stimulation with dynamic rehabilitation enables standing and stepping
Fabien Wagner (University of Bordeaux) – Spinal cord stimulation for lower-limb motor neuroprostheses
Marco Capogrosso (University of Pittsburgh) – Spinal cord stimulation for upper-limb motor neuroprostheses
Lee Fisher (University of Pittsburgh) – Spinal cord stimulation for sensory neuroprostheses

Session Description:

Spinal cord stimulation (SCS) is a well-established clinical therapy for treating chronic pain. However, SCS is actively being investigated as an approach to treat additional neurological disorders. This session will cover some of these emerging applications, such as alleviating gait dysfunction in Parkinson’s disease, enabling motor control, and restoring sensory function.



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Completed The therapeutic effect of non-invasive brain stimulation techniques on motor functions.

Starts: Wednesday, April 22nd 2020 | 10 AM (EDT) / 15:00 (GMT+1)
Duration: 1 hour

Session Chair:

Giuseppina Pilloni, NYU Langone, Dep. of Neurology

Session speakers:

Dr. Dylan J. Edwards, Moss Rehabilitation Research Institute, USA
Dr. Leigh Charvet, NYU Langone, USA
Dr. Alberto Benussi, Università degli Studi di Brescia, ITALY
Dr. Fabian Steinberg, Louisiana State University, USA
Dr. Kush Sharma, NYU Langone, USA
Dr. Charlotte Stagg, University of Oxford
Dr. Gottfried Schlaug, Baystate Health
Dr. Alexandre Okano, Universidade Federal do ABC

Session Description:

Any kind of rehabilitation is aimed at ameliorating clinical symptoms by modulating neuronal activity, inducing long-lasting effects over time. Recently, non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (TES), have been proposed as valid tools to treat symptoms related to neurological conditions, mainly for the potential synergy with rehabilitation and as add-on treatment for motor symptoms.



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Completed Hybrid brain models for personalization and optimization of tCS/tES: a journey across scales

Starts: Wednesday, April 22nd 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 2 hours

Session Chair:

Giulio Ruffini (Neuroelectrics)

Session Speakers:

Gustavo Deco (UPF Barcelona)
Stephanie Jones (Brown U.)
Fabrice Wendling (LTSI - UMR Inserm - U. de Rennes)
Aman Aberra (Duke U)

Session Description:

In the next decades, computational models of the brain will play a key role in the personalization of therapies, reducing uncertainty in clinical trials by reflecting individual biophysical and physiological characteristics. Efforts in the last decade have focused on accurate modeling of the electric fields generated by tCS/tES as a first-order predictor of stimulation outcomes from, ideally, personalized from MRI data for each subject. Indeed, a physical model can provide better control and dosing in experimental protocols with multiple small electrodes than the specification of currents at electrodes in bipolar montages. Based on such physical models, objective functions for optimization can be defined using simple physiological interaction models such as the lambda-E model, linking E fields with membrane polarization. However, the next generation of models should combine passive physical properties with more sophisticated representations of the physiological effects of tCS, both concurrent and long term.Such computational hybrid approaches providing links with measures obtained from fMRI, EEG or TMS will enable the creation of personalized models and guide the optimization of protocols, including the specification of targets, dosing (e.g., desired electric fields), and the selection of metrics for open or closed -loop interventions. They can also provide a powerful platform to gain mechanistic insights. While relevant to NIBS in general, in this symposium we take a multiscale approach to advance this ambitious program in the context of tCS.



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Completed Survivors in Neuromodulation: Lessons learned and wisdom gained from the entrepreneur survivors of the 2008-09 financial downturn

Starts: Wednesday, April 22nd 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 1 hour

Session Moderator:

Moderator: Jennifer French, Neurotech Network

Discussion with
Jon Synder, Neuros Medical
Audience Discussion:
Ladan Jiracek, Neural Implant Media

Session Description:

Tumultuous economic times are ahead as we start down the road of an economic downturn. How do we survive this one? Guidance through difficult times can steer neurotech translation and early ventures in the right direction. Business wisdom can prevent costly and catastrophic mistakes. Even one good piece of advice can make the difference between failure and survival. Let's take the time to learn from the experiences of those who survived the 2008-09 financial crisis. This session will consist of a discussions with neuromodulation entrepreneurs who were either starting their companies or raising investment capital during the last economic downturn. Hear about lessons learned and the survival tactics used to get through those times. This session will also introduce the Neurotech Entrepreneur Working Network to build an online community for neurotech developers, translators and entrepreneurs. Audience participation is encouraged!



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Completed Mechanisms of Transcranial Electric Stimulation

Starts: Wednesday, April 22nd 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 3 hours

Session Chair:

Lucas Parra, City University of New York

Session Speakers:

11:00 EDT Javier Marquez Ruiz Exploring neuronal mechanisms underlying tES effects in alert mice
11:20 EDT Hanoch Kaphzan Presynaptic mechanisms of tDCS
11:40 EDT Hajime Hirase Microglial activation by tDCS in awake mice
12:00 EDT Stefan Rotter Homeostatic network remodeling induced by TES
12:20 EDT Greg Kronberg DCS boosts Hebbian plasticity
12:40 EDT Klaus Obermayer Computational modelling of current stimulation and neural populations
13:00 EDT Flavio Frohlich Arnold Tongue as the Mechanism of Transcranial Alternating Current Stimulation (tACS)?
13:20 EDT Mihály Vöröslakos Instantaneous neuronal effects of TES in vivo (When and Why do we need it?)

Session Description:

This session will invite a number of investigators working to elucidating the basic mechanisms of action of electric stimulation on the brain. We will invite speaker doing experimental work in model systems, including computational modeling


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Completed Electric Field Modeling in tDCS: Applications in Trial Design and Analysis

Starts: Wednesday, April 22nd 2020 | 11 AM (EDT) / 16:00 (GMT+1)
Duration: 2 hours

Session Chair:

Kevin Caulfield (MUSC)

Session Speakers:

Axel Thielscher, PhD, Danish Research Centre for Magnetic Resonance. "Magnetic Resonance Current Density Imaging for validating simulated electric fields"
Ivan Alekseichuk, PhD, University of Minnesota. "Electrical Field Modeling for Translational Research in Animals and Humans"
Aprinda Indahlastari, PhD, University of Florida. "Modeling tDCS Electric Field in the Aging Brain"
Kevin Caulfield, PhD Student, Medical University of South Carolina. "Reverse-calculation electric field modeling for individualizing tDCS dose."

Session Description:

tDCS is an enticing brain stimulation tool but has limited methods of measuring how much stimulation reaches the brain. In this symposium we discuss how electric field modeling based on anatomical MRI scans could help to assess dose-response relationships and possibly individualize stimulation dosage in the future.



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Completed The Alliance for Advancing Bioelectronic Medicine: A Unique Platform for Collaboration, Stakeholder Engagement, and Public Positioning

Starts: Wednesday, April 22nd 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 30 minutes

Session Speakers:

• Mario Ottiglio, AABM Secretariat
• Barry Keenan, BioSig Technologies
• AABM Member, TBD

Session Description:

Learn about the Alliance for Advancing Bioelectronic Medicine (AABM) – a new, independent network of professionals joining together to unite the field of bioelectronic medicine and engage investors, physicians, patients, regulators, and payers.
AABM aims to align bioelectronic medicine leaders, including those in neuromodulation, facilitate cross-sector collaboration, mobilize key external audiences, and build awareness of the field overall. AABM’s founding members include representatives from the Mayo Clinic, the Heart Rhythm Society, the European Heart Rhythm Association, the Feinstein Institutes for Medical Research, Battelle, and others.
The session will cover:
• The Alliance’s founding vision, goals, members, and progress to-date
• Why the field needs an organization like AABM
• Interview with an AABM member on the organization’s work and value
• Brief Q&A session



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Completed Utilizing Network Imaging to Personalizing and Optimizing Neuromodulation in Translational Cognitive Neuroscience

Starts: Wednesday, April 22nd 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 1 hour

Session Chair:

Roy Hamilton, MD, MS (University of Pennsylvania)

Session speakers:

John Medaglia, PhD (Drexel University)
Desmond Oathes, PhD (University of Pennsylvania)

Session Description:

Recent years have seen explosive growth in our understanding of the functional organization of the human brain. Much of this expansion derives from advances in the tools, techniques, and concepts used to represent the brain’s complex and dynamic network properties. These developments have, in turn, given rise to advances in the ability to modify brain circuits with ever increasing precision, making it possible to apply neuromodulation that is specific at the level of individuals. This session will highlight innovations in the personalization of neuromodulation and will present promising data that suggests that these advances in precision may afford greater efficacy in the enhancement of cognition and the treatment of brain disorders.


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Completed Noninvasive Vagus Nerve Stimulation Applied to Stress Management, Opioid Withdrawal, and Neurocognitive Disorders

Starts: Wednesday, April 22nd 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 2 hours

Session Chair:

Nil Gurel (Georgia Tech)

Session Speakers:

Asim Gazi, PhD Student, Georgia Tech (speaker)
Matthew T. Wittbrodt, PhD, Emory School of Medicine (speaker)
J. Douglas Bremner, MD, Emory School of Medicine and Atlanta VA (speaker)
Ihab Hajjar, MD, Emory School of Medicine (discussant)
Omer T. Inan, PhD, Georgia Tech (discussant)
Marom Bikson, PhD, City University of New York (discussant)
Bashar Badran, PhD, Medical University of South Carolina (discussant)
Zhi-De Deng, PhD, Computational Neurostimulation Research Program, Noninvasive Neuromodulation Unit, NIH/NIMH (discussant)
William T. Regenold, MDCM, Noninvasive Neuromodulation Unit, NIH/NIMH (discussant)

Session Description:

The presenters and discussants in this session will discuss the applications of noninvasive vagus nerve stimulation (nVNS) to stress management, opioid withdrawal and neurocognitive disorders. The speakers will present the effects of nVNS in the context of stress and PTSD with investigations in multiple dimensions: downstream physiological biomarkers, brain imaging, and blood biomarkers. We will extend the discussion to other psychiatry-related applications of nVNS, such as for patients with opioid use disorders during withdrawal and for enhancing learning in patients with Alzheimer’s disease. Engineering discussions will focus on potential wearable technologies to translate nVNS technologies from clinics and labs to homes. This session welcomes early career stage researchers, engineers, and physicians interested in psychiatry and neurology focused applications of nVNS. Session contact: Nil Gurel (Georgia Tech, nil@gatech.edu)



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Completed Clinical Evidence and Programming Techniques for Neuromodulation of Dorsal Root Ganglion and Deep Brain Stimulation

Starts: Wednesday, April 22nd 2020 | 12 PM (EDT) / 17:00 (GMT+1)
Duration: 1 hour

Session Speakers:

Clinical Evidence for Dorsal Root Ganglion Stimulation (Alex Benison, Abbott)
DRG stimulation with BurstDR (Hyun-Joo Park, Abbott)
Evidence-based Directional Programming in Deep Brain Stimulation (DBS) for Parkinson’s disease and Essential Tremor (Srivatsan Pallavaram, Abbott)
Steering the Volume of Tissue Activated with A Directional Deep Brain Stimulation Lead in the Globus Pallidus pars internal (GPi) (David Zhang, Abbott)

Session Description:

This session will review the clinical evidence of Dorsal Root Ganglion (DRG) stimulation for relieving pain of the lower limbs due to CRPS and causalgia and Deep Brain Stimulation (DBS) for the treatment of movement disorders like Parkinson’s disease and essential tremor. This session will also discuss waveforms and programming settings used in DRG and the more recent approaches available for DBS programming in STN, Vim and GPi targets with an emphasis on directional DBS. Also, we will have a discussion describing a chronic pain rodent model study which compares DRG stimulation using BurstDR with tonic stimulation. The effect of directional DBS electrode configuration and vertical electrode spacing on the volume of tissue activated (VTA) in the globus pallidus pars interna (GPi) will be evaluated based on computational modeling.



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Completed Transcranial Pulse Stimulation (TPS) with ultrasound as a revolutionary new brain therapy

Starts: Wednesday, April 22nd 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 1 hour

Session Chair:

Abhishek Datta, Soterix Medical

Session speakers:

Roland Beisteiner, Medical University of Vienna, Vienna, Austria
Pavel Novak, STORZ MEDICAL AG, Tägerwilen, Switzerland

Session Description:

Ultrasound-based brain stimulation may become a powerful new technique to modulate the human brain in a focal and targeted manner. For the new ultrasound technique TPS, longterm benefits for Alzheimer’s patients have already been published. Due to its unprecedented clinical capabilities for precise network targeting and deep brain stimulation, particular TPS advantages are also expected for therapy of movement disorders.
The presentation will introduce the new clinical sonication technique TPS (Transcranial Pulse Stimulation), which is based on single ultrashort ultrasound pulses, which markedly differ from existing focused ultrasound techniques. Details from the comprehensive preclinical and clinical study using ultrasound brain stimulation in 35 Alzheimer’s patients with first observations of clinical long-term effects are presented (Beisteiner et al. 2020). The preclinical TPS results show large safety margins and dose dependent neuromodulation. The patient results reveal high treatment tolerability and no major side effects. Neuropsychological scores improve significantly after TPS treatment and improvements last up to three months and correlate with an upregulation of the memory network (fMRI data).
Further, an outlook on benefits for movement disorders and other network specific diseases will be given.
References:
Beisteiner R, Matt E, Fan C, et al. Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease—A New Navigated Focal Brain Therapy. Advanced Science 2020, 7, 1902583. doi:10.1002/advs.201902583
Abbasi J. Ultrasound Brain Stimulation Piloted in Alzheimer Study. JAMA 2020;323(6):499. doi:10.1001/jama.2020.0471



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Completed Neurotech Media Communication and Career Benefits

Starts: Wednesday, April 22nd 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 30 minutes

Session Speakers:

Ladan Jiracek- Neural Implant Media
JoJo Platt- Platt and Associates
Avery Bedows- The Substrate Group

Session Description:

Do you want to better communicate your science, technology, or products? Communicating and promoting your organization's work is one of the key things done by the most successful industry leaders and researchers. This is the one thing that can have outsized positive impacts on your career. Listen in as our team of 3 of the leading neurotech communicators weigh in on the results of effectively communicating your neurotech work.



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Completed Real Time MRI of Neuromodulation in Human Brain

Starts: Wednesday, April 22nd 2020 | 1 PM (EDT) / 18:00 (GMT+1)
Duration: 2 hours

Session Chair:

Danny JJ Wang, PhD, Professor of Neurology and Radiology, University of Southern California (USC)

Session Speakers:

Rosalind Sadleir, PhD, Associate Professor of Electrical Engineering, Arizona State University
Mayank Jog, PhD, Postdoctoral Research Fellow, University of Southern California (USC)
Yihong Yang, PhD, Senior Investigator, Chief of Neuroimaging Research Branch, National Institute of Drug Abuse (NIDA)
Dr. med Wolf-Julian Neumann, Associate Researcher, Department of Neurology, Charité - University Medicine Berlin

Session Description:

During recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS), have become an important means to study how complex neural circuits interact in the brain, through stimulation or modulation of neuronal activities, to manipulate human cognition and to treat brain disorders. With the latest technical advances, MRI can now be performed concurrently with these neuromodulation techniques to visualize their effects on the human brain in real time, to understand the neurophysiological mechanism and to improve their efficacy. In this symposium, Dr. Rosalind Sadleir will first introduce the MR Electrical Impedance Tomography (MREIT) technique that enables the measurement of current density distributions during tDCS in-vivo. Dr. Mayank Jog will then present a novel imaging technique that enables concurrent mapping of the tDCS current induced magnetic field and neurophysiological changes using MRI. Drs. Yihong Yang and Julian Neumann will then present new findings using concurrent MRI and TMS, as well as concurrent MRI and DBS, respectively. The 4 speakers are leaders of the field with diverse backgrounds and international representations. Finally, the audience will have opportunities to interact with the speakers through panel discussion.


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Completed EEG with noninvasive brain stimulation (NIBS): Artifacts, Modeling, and Removal

Starts: Wednesday, April 22nd 2020 | 3 PM (EDT) / 20:00 (GMT+1)
Duration: 2.5 hours

Session Chair:

Nigel Gebodh (The City College of New York)
Zeinab Esmaeilpour (The City College of New York)

Session speakers:

Nigel Gebodh (The City College of New York)
Dr. Alex Casson (The University of Manchester)
Dr. Soojin Lee (The University of British Columbia, Canada)
Dr. Florian Kasten (Carl von Ossietzky University Oldenburg, Germany)
Dr. Leo Tomasevic (Copenhagen University Hospital, Denmark)
Dr. Tuomas Mutanen (Aalto University, Finland)

Session Description:

Concurrent noninvasive transcranial electrical (tES) as well as magnetic stimulation (TMS) and neuroimaging is highly valuable since it enables monitoring underlying neural activity while applying neuromodulatory techniques. Stimulation artifacts are one of the major obstacles when it comes to combining tES or TMS with M/EEG since stimulation related artifacts can be non-linear, and highly overlap with frequency of neural activity. In this session we will discuss combining tES or TMS with M/EEG in terms of artifacts, artifact modeling, and removal and attenuation techniques.



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Completed Many happy returns: How engaging with patients/end-users can improve clinical execution and economics in neuromodulation development

Starts: Wednesday, April 22nd 2020 | 3 PM (EDT) / 20:00 (GMT+1)
Duration: 1 hour

Session Speakers:

Susan Schaeffer, Patient Academy for Research Advocacy
Jennifer French, Neurotech Network
Round table discussion: Yagna Pathak, Abbott Neuromodulation, Blythe Karow, Evren Technologies, Cara Altimus, Milken Institute

Session Description:

Join Neurotech Network and The Patients’ Academy for Research Advocacy to learn how engaging with end-users throughout the R&D cycle can improve research quality and efficiency—and deliver favorable returns. We’ll present the business case for patient engagement using case studies and quantitative analyses from other organizations in the health field, and discuss how neuromodulation companies can get started with patient engagement programs that build trusting relationships and improve research quality, timelines and ultimately save precious development funds. The round table discussion will feature industry representatives who have successfully implemented patient engagement programs and will share lessons from the frontlines.

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Completed Neuroimaging with Simultaneous tDCS: Markers and Outcomes in Multiple Sclerosis

Starts: Wednesday, April 22nd 2020 | 3 PM (EDT) / 20:00 (GMT+1)
Duration: 2 hours

Session Chair:

Marco Muccio (NYU School of Medicine Department of Radiology)

Session Speakers:

Lillian Walton Masters (NYU School of Medicine Department of Neurology)
Dr. Yulin Ge (NYU School of Medicine Department of Radiology)
Dr. Leigh Charvet (NYU School of Medicine Department of Neurology).

Session Description:

We will review our protocol for simultaneous tDCS and MRI measured in MS patients before and after 20 sessions of tDCS treatment targeting fatigue and cognition. Findings will be presented to 1) compare real-time tDCS response in MS patients to healthy controls, and 2) to demonstrate changes in MS patients after cumulative tDCS sessions, with the goal of identifying predictors of clinical response.



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Completed Advanced approaches to spinal cord stimulation for pain

Starts: Wednesday, April 22nd 2020 | 3 PM (EDT) / 20:00 (GMT+1)
Duration: 2 hours

Session Chair:

Scott Lempka (University of Michigan)

Session Speakers:

Melanie Goodman Keiser (Medtronic) – High-dose spinal cord stimulation
Kerry Bradley (Nevro) – Basis science of kilohertz-frequency spinal cord stimulation
Natalie Brill (Abbott) – Basic science of burst SCS and clinical evidence for low energy settings
Tianhe Zhang (Boston Scientific) – Model-based optimization of spinal cord stimulation

Session Description:

Spinal cord stimulation (SCS) has been used clinically for several decades to help treat chronic pain. Over the last several years, there have been tremendous advances in commercial SCS technologies. Some of these advances include novel waveform patterns, model-based optimization of stimulation parameters, and closed-loop control. This session will include speakers from industry describing innovative aspects of SCS technologies.



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Completed Combining Imaging and TMS for targeted modulation of frontal and motor brain networks

Starts: Wednesday, April 22nd 2020 | 4 PM (EDT) / 21:00 (GMT+1)
Duration: 1 hour

Session Speakers:

Sumitash Jana, Postdoc, University of California San Diego (speaker): Prefrontal beta precedes the temporal cascade of events underlying action stopping
Ricci Hannah, Project Scientist, University of California San Diego (speaker): Temporally-precise disruption of prefrontal cortex informed by the timing of beta bursts impairs human action-stopping
Kelsey Sundby, Graduate Student, University of California San Diego (speaker/organizer): Double blind disruption of right inferior frontal cortex erodes right frontal beta power for action-stopping
Vignesh Muralidharan, Postdoc, University of California San Diego (speaker): Can we drive cortical oscillatory activity using rhythmic TMS to probe brain-behavior relationships?

Session Description:

In this session we will present our recent work using neuroimaging methods to guide TMS-based causal interrogation of specific brain networks involved in action control. In three different studies, we use: 1) online TMS to disrupt a prefrontal network in a time specific-manner, 2) offline TMS to exert long-lasting effects on this network (>10min), and 3) offline TMS to test whether we can drive cortical oscillations in order to examine their role in behavior.


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Completed Using the human connectome to identify targets for neuromodulation

Starts: Wednesday, April 22nd 2020 | 4 PM (EDT) / 21:00 (GMT+1)
Duration: 2 hours

Session Chair:

Shan H. Siddiqi, MD (Harvard Medical School, Beth Israel Deaconess Medical Center)

Session Speakers:

Alexander L. Cohen, MD, PhD (Harvard Medical School, Boston Children's
Fatimah Albazron, MS (University of Iowa)
Mark Bowren, BS (University of Iowa)

Session Description:

Drs. Siddiqi and Cohen will first introduce the topic of lesion network mapping, a technique used to link behaviors to underlying brain networks based on the connectivity of causal brain lesions. We can map this connectivity using the human connectome, a wiring diagram of the human brain derived using 1000 healthy individuals. This approach is unique because it utilizes causal sources of information rather than correlational neuroimaging. This type of causal mapping can reveal promising therapeutic targets for neuromodulation.
Dr. Cohen will illustrate this point by describing a pathway to identifying neuromodulation targets in non-lesional neurodeveopmental disorders. In this talk, he will discuss the application of lesion network mapping to symptoms present in both adults and children, as well as the potential utility of using developmental anomalies for network analysis.
Dr. Ferguson will discuss a human memory circuit derived using 53 case reports of strokes. Its hub is at the junction of the presubiculum and retrosplenial cortex. This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer’s disease, and brain stimulation sites reported to enhance memory in humans.
Fatimah Albazron will discuss network localization of cerebellar cognitive affective syndrome (CCAS), a syndrome of emotional lability, executive dysfunction, and language impairment after cerebellar lesions or tumor resection. Lesion network localization revealed the cerebellar outflow pathway and its projection to the mediodorsal nucleus of the thalamus as key structures implicated in CCAS.
Mark Bowren will discuss network localization of general cognitive ability using based on 422 neurological patients with focal brain lesions. This approach revealed deep white matter underlying the left temporoparietal junction as critical for general cognitive ability.
Finally, Dr. Siddiqi will describe the therapeutic implications of these approaches. Network localization can also be applied to neuromodulation sites, revealing distinct TMS targets for different symptoms of major depression. This approach can also be applied to translate targets between lesions, TMS, and DBS. This will demonstrate how various lesion network mapping studies can be directly applied to clinical therapeutics.



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